Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

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Dexmedetomidine for pediatric sedation for computed tomography imaging studies. Inttanasal non-DEX cohort had more subjects in the deep sedation cohort, subjects Parental separation was successful in Phan H, Nahata M.

This practice is gaining more popularity amongst sedation providers outside of the operating room due to a decrease in emotional inntranasal in children that is related to the IN administration route. Evidence supports the use of dexmedetomidine for sedation in mechanically ventilated adult patients.

Comparison of the nasal and sublingual routes. A double-blinded randomized controlled trial. Increasing evidence has shown that dexmedetomidine is an effective and safe sedative in children scheduled for radiological procedures. Int J Clin Pharmacol Ther. In this study, we hypothesized that IN DEX is effective in providing adequate sedation for non-invasive procedures.

Cardiovascular effects of dexmedetomidine sedation in children. Premedication is required to alleviate anxiety and fear, allow smooth separation from parents, and allow easy acceptance of needle prick for intravenous cannulation and anesthesia induction. Sixteen of 30 children Open in a separate window. Various drugs are available for premedication, with midazolam being the most commonly used. Subjects 6 months to 18 years of age undergoing non-invasive elective procedures were included.


A comparative evaluation of intranasal dexmedetomidine, midazolam and ketamin for their sedative and analgesic properties: We created a database capturing all the relevant demographics and events for children undergoing sedation for elective, non-invasive outpatient procedures. Comparison of level of sedation between the groups at the time of induction.

An alternative to benzodiazepines for premedication in children. A randomized study of intranasal vs. However, it is my belief that IN dexmedetomidine given alone or in combination with another drug such as ketamine may have broad application for sedation in children.

Dexmedetomidine is known to decrease sympathetic outflow and circulating catecholamine levels. However, midazolam is associated with respiratory depression and an increased incidence of adverse postoperative behavioral changes, hiccups, and paradoxical reactions.

However, midazolam is associated with the risk of respiratory depression and has no analgesic action.

Intranasal Dexmedetomidine as a Sedative for Pediatric Procedural Sedation

To our knowledge, sleep time and the use of DEX in any formulation has not been previously observed. It acts on the locus coeruleus and produces an unusually cooperative form of sedation, in which the patient is calmly and easily aroused from sleep to wakefulness and subsequently quickly falls back asleep when not stimulated, which is similar to natural sleep. Prior to investigation, our institutional review board reviewed the study and approved the investigation.


Except for a longer sleep time, IN DEX was not associated with a higher incidence of adverse events when compared to a cohort that did not receive DEX sedation.

Please review our privacy policy. We compared hemodynamic and respiratory parameters, onset, level, sedation quality, and successful parental separation.

Intranasal Dexmedetomidine as a Sedative for Pediatric Procedural Sedation

Thanks for the interesting topic. Contrastingly, dexmedetomidine does not cause any transient nasal burning or irritation, paradoxical reaction, hiccups, and respiratory depression. The difference in onset time was statistically significant with early onset in midazolam. Financial support and sponsorship Nil.

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

Our secondary objective was to evaluate the safety profile of IN DEX compared to well-established intravenous sedative medications i. Subjects were included if they were 6 months to 18 years of age, undergoing non-invasive procedures i.

The mean age and weight were 2.