FORMAS FARMACEUTICAS SOLIDAS PDF

FORMAS FARMACEUTICAS SOLIDAS PDF

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Sustained release solid oral dosage forms: Sustained release solid oral dosage forms are characterized by the gradual release of the drug and maintenance of its plasmatic concentration in therapeutic levels, during a prolonged period of time.

They can be designed as single-unity or multiple-unity dosage forms, using technologies such as matrix, reservoir or osmotic systems. The present work is a review on the technologies used to obtain sustained release oral dosage forms, with a special attention to the technological and biopharmaceutical benefits of multiple-unity over single-unity systems.

The methods used in the evaluation of the dissolution characteristics of such systems are also approached. Examples of products available in the Brazilian market are shown with the purpose of illustrating the applicability of sustained release solid oral dosage forms, besides verifying the profile of utilization of these systems by the national industry.

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Solid oral dosage forms.

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Os objetivos podem ser: Menor risco de “dose dumping”. Os autores agradecem a D. Translocation of drug particles in HPMC matrix gel layer: Tableting of coated pellets. New and extended applications for USP drug release apparatus 3.

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Swellable matrices for controlled drug delivery: PSTTAmsterdam, v.

Oral solid dosage forms. Pharmaceutical preformulation and formulation.

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Matrix mini-tablets based on starch: Development and evaluation of oral multiple-unit and single-unit hydrophilic controlled-release systems.

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Influence of formulation and process parameters on pellet production by powder layering technique.

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Research and development aspects of oral controlled-release dosage farmacfuticas. Handbook of pharmaceutical controlled release technology, New York: In vitro controlled release of vinpocetine-cyclodextrin-tartaric acid multicomponent complexes from HPMC swellable tablets.

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United States Pharmacopoeial Convention, An overview of controlled release systems. Handbook of pharmaceutical controlled release technology. Formulation aspects in the development of osmotically controlled oral drug delivery systems. Encyclopedia of Biomaterials and biomedical engineering. Investigation of the pellet-distribution in single tablets via image analysis. Mechanism of particle coating granulation with RESS process in a fluidized bed.

Evaluation of USP apparatus 3 for dissolution testing of immediate-release products. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Services on Demand Journal. ABSTRACT Sustained release solid oral dosage forms are characterized by the gradual release of the drug and maintenance of its plasmatic concentration in therapeutic levels, during a prolonged period of time.

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