This is an important contribution, adding to the understanding of bone remodeling, which is not just relevant to arthritis but also to degenerative bone changes. Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture. Whereas degenerative osteoarthritis results in the formation of new . Figure 3 New bone formation next to inflamed joints is increased upon blockade of DKK (a) Microphotographs of toluidine blue–stained joint sections of, ”from.

Author: Yozshura Arashigami
Country: Georgia
Language: English (Spanish)
Genre: Travel
Published (Last): 18 March 2010
Pages: 485
PDF File Size: 5.78 Mb
ePub File Size: 3.76 Mb
ISBN: 612-1-13088-699-3
Downloads: 77281
Price: Free* [*Free Regsitration Required]
Uploader: Dira

Recently, conflicting evidence has been obtained regarding the role of DKK-1 in cell migration. Topics Discussed in This Paper.

Dickkopf-1 is a master regulator of joint remodeling.

They were all female patients and provided written informed consent. F does not claim any ownership in the Material that you or any other user rsmodeling. Figure 3 New bone formation next to inflamed joints is increased upon blockade of DKK Osteophyte tumor necrosis Neurodegenerative Disorders Bone Resorption.

Scale bar, 40 mm. Certain parts of this website offer the opportunity for jjoint to post opinions, information and material including without limitation academic papers and data ‘Material’ in areas of the website.

Dickkopf-1 is a master regulator of joint remodeling

You have a close personal relationship e. Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. Rheumatoid Arthritis Search for additional papers on this topic.

S1available at Rheumatology Online.

The rate of migration was calculated by measuring between the fronts of the wound after scratching as follows: Showing of 34 references.


Bone Loss in Rheumatoid Arthritis: Please disclose any competing interests that might be construed rekodeling influence your judgment of the validity or importance of the article, or any recommendation or review.

Receive exclusive offers and updates from Oxford Academic. Gravallese Immunological reviews You must accept the terms and conditions.

Laminin regulates mouse embryonic stem cell migration: Register Already registered with FPrime? Black arrows indicate areas of remoeling deposition.

Dickkopf-1 is a master regulator of joint remodeling.

You are entitled to post or upload the Material on the website and have all necessary licenses and consents to do so; the Material does not infringe any intellectual property right, including without limitation copyright, patent or trademark, or other proprietary right of any third party; the Material does not contain any defamatory, libellous, offensive, indecent or otherwise unlawful material or material which is us invasion of privacy; the Material does not contain any contaminating or destructive features or devices such as viruses, time bombs or coding designed to interrupt, destroy or limit the dickkkpf-1 of this website or any of this website’s user’s computer equipment or software; the Material will not be used to solicit or promote regulatpr or custom or present commercial activities or unlawful activity; and the Material is in compliance with all applicable laws.

F reserves the right to remove any comments that it considers in its absolute discretion to be reghlator, offensive or otherwise in breach of the Terms and Conditions dockkopf-1 to Materials including Comments.

As shown in Fig. It has also been established that the RA FLSs have the potential to migrate to locally adjacent joint tissues susceptible to matrix destruction and even to distant unaffected joints through the bloodstream [ 2—5 ]. Cells were replaced with serum-free media and treated with the appropriate drugs in a CO 2 incubator for 24 h.


Integrins, which comprise a family of heterodimeric transmembrane proteins that link to ECM proteins such as fibronectin, vitronectin and laminin, regulate both cell migration and tissue remodelling [ 30 ]. Development of criteria for the classification and reporting of osteoarthritis.

I am a Faculty Member who recommended this article. F reserves the right to monitor all Material and to remove any Material which it considers in its absolute discretion to be unlawful, inappropriate, offensive or otherwise in breach of these Terms and Conditions. I am an author of this article. We identified tumor necrosis factor-alpha TNF as a key inducer of DKK-1 in the mouse inflammatory arthritis model and in human rheumatoid arthritis.

Figure 3 from Dickkopf-1 is a master regulator of joint remodeling – Semantic Scholar

References Publications referenced by this paper. Neither of the above. Classification of osteoarthritis of the knee. Of these protein tyrosine kinases, FAK plays a prominent role in integrin signalling and has been implicated in a diverse array of cellular processes, including cell migration, growth factor signalling and cell survival [ 19 ]. Williams Journal of bone and mineral research: