Integrating multi-parameter microscopy data: organization and plasticity of cancer metastasis. Peter Friedl M.D., Ph.D. 1 Radboud University Nijmegen Medical. Plasticity of cell migration determined by tissue organization Thereby, the density of the ECM determines the invasion mode of mesenchymal tumor cells. Tumour-cell invasion and migration: diversity and escape mechanisms. P Friedl Cancer invasion and the microenvironment: plasticity and reciprocity. P Friedl.
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BioRxiv, Nature Biomedical Engineering 1 Cancer invasion is initiated and maintained by signaling pathways that control cytoskeletal dynamics in tumor cells and the turnover of cell-matrix and cell-cell junctions, followed by cell migration into the adjacent tissue.
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
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