Etude épidémiologique de la bronchite chronique dans une population agée de 60 à 85 ans. Contributions à l’étude de l’histoire naturelle de la. Les signes propres de la bronchite chronique distale et de l’emphysème au cours des syndromes de bronchopneumopathie dyspnéisante. Download Citation on ResearchGate | Physiopathologie de la toux | Cough is initiated from organs innervated by the vagus nerve. The larynx and the lower.

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Mechanisms that involve the formation and persistence of thrombus leading to a fibrous vascular remodeling remain unknown. Several functional disturbances related to molecular abnormalities have been identified.

This work has been able to demonstrate the abnormal phenotype of endothelial cells taken from thrombus of CTEPH and molecular anomalies in the origin of this dysfunction. French 15 Portuguese 1. The first project demonstrated a dendritic cells dysfunction and a Th17 immune polarization of idiopathic PAH patients.

Patterns of dynamic hyperinflation during exercise and recovery in bronchie with severe chronic obstructive pulmonary disease. In PAH, glutamate accumulates in pulmonary arteries, and endothelin-1, a major actor of the PAH-associated vascular remodeling, triggers glutamate release from smooth muscle cells. In a first study, we investigated PH screening with echocardiography in patients with advanced lung disease.

Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique (Ile-de-France)

Chronic obstructive pulmonary disease. This work could help to develop new therapies allowing chrobique specific and more effective treatments leading to improved survival of PAH patients. The objective of the second project was to study the epigenetic variations in pulmonary endothelial cells PEC physiopatholobie a specific pattern of DNA methylation.

A better understanding of the role of endothelial dysfunction in PAH immune system dysregulation may help to the development of new therapeutical strategies for this disease.

We compared two different piglet models of pulmonary hypertension. In this work, we highlighted the existence of an aberrant communication between pulmonary endothelium and immune system in PAH and showed that pulmonary endothelium chroniquue a key role in the control of adaptive responses, by regulating regulatory T lymphocyte function in a leptin-dependent manner, and by actively participating to the innate responses through a pro-inflammatory phenotype.


However, an impairment of the myocardial microvascularisation could lead to myocardial ischemia and could participate to the transition between adapted and non-adapted right ventricular hypertrophy.

Avec l’aggravation de l’obstruction bronchique, le temps expiratoire ne permet plus une expiration normale. Taking together, these results showed that microvascular impairment and mitochondrial dysfunction had an important role in the early right ventricular dysfunction.

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Molecular pathways involved in both mechanisms are currently studied to find new targeted therapeutics. Contact Help Who are we? Smoking characteristics – Differences in attitudes and dependance between healthy smokers and smokers with COPD.

As mitochondrion are involved in the entire oxygen-dependent energy production in cardiomyocytes, their integrity is also essential for a good right ventricular function. Moreover, environmental and genetic factors may predispose to this vascular disease. The aim of this thesis was to evaluate non-invasive screening of PH with echocardiography and to study the pathophysiology of acute right heart failure in the setting of chronic PH by performing precise phenotyping of a new large animal model.

We reproduced and described the main morphological and functional features observed in acute right heart failure on PH and we showed for the first time that acute right ventricular ischemic lesions may develop within few hours despite hemodynamic restauration pnysiopathologie dobutamine.

BPCO – Bronchite Chronique – – Documentation sur les BPCO

Acute exacerbation of chronic bronchitis: Increasing evidence are also suggesting the importance of immune disorders, such as autoimmunity, in PAH pathophysiology. A wide review of anatomic, embryologic and physiologic concepts was performed to help for the understanding of parameters of RV evaluation; then published and ongoing original studies were presented. Agency for healthcare research and quality, september Facteurs pronostiques des BPCO.

Our pathophysiologic results could improve patient’s stratification in chronic pulmonary hypertension. The recent progress in the understanding of mechanisms at the origin of this disease underlines the role of extrapulmonary cells, such as circulating stem cells and bone marrow-derived progenitor cells in vascular remodeling and in PAH development.


BPCO avec insuffisance respiratoire: Action plans for chronic obstructive pulmonary disease. Capillary density was not chroniquue between physiopathologle two groups and was almost 1. However, the pathophysiology of the transition from adaptive to maladaptive phenotypes remains unclear; and identification of RV therapeutic targets and noninvasive methods for its evaluation remains to developed.

This project allowed to study three biological process clearly establish to be implicated in physiopathology of PAH. It is also present in peripheral cells, including aortic and cerebral vascular cells, and promotes their proliferation.

The mitochondrial mass assessed in transmission electronic microscopy was not decreased.

These work aimed to clarify and better understand the abnormal phenotype of the pulmonary endothelial cell P-EC of PAH patients to identify new therapeutic targets to correct and chronqiue the endothelial dysfunction associated with physiopathologiw hypertension.

Vasoconstriction, pulmonary vascular remodeling, in situ thrombosis and endothelial dysfunction are all factors that contribute to the development and progression of the disease. The population had mean age of 58 years with female majority, most of the patients were in functional class III, 23 had pulmonary arterial hypertension PAH and 39 had chronic thromboembolic pulmonary hypertension CTEPH.

In the second part of this thesis, we studied and compared the capillary density and myocardial fibrosis in right ventricles of 14 Eisenmenger Syndrome patients and 14 physiopatho,ogie with chronic pulmonary arterial hypertension.

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